Centro de Documentação da PJ
Monografia
 CD258 |
Comprehensive forensic toxicological analysis of designer drugs [Documento electrónico] : final technical report / Anthony P. DeCaprio, W. Lee Hearn, Madeleine J. Swortwood.- [Rockville, MD] : National Criminal Justice Reference Service (NCJRS), 2013.- 1 CD-ROM ; 12 cm
Research report submitted to the U.S. National Institute of Justice, Office of Justice Programs. Ficheiro de 1,61 MB em formato PDF (53 p.).
DROGA SINTÉTICA, ANÁLISE LABORATORIAL, ESTUPEFACIENTE, TOXICOLOGIA
«"Designer drugs" are analogs or derivatives of controlled substances that are sold on the street in an attempt to circumvent the legal restrictions placed on scheduled drugs. New designer drugs are constantly emerging onto the illicit drug market and it is often difficult to validate and maintain comprehensive analytical methods for accurate detection of these compounds. Chemical modifications in these substances can be very subtle, leading to virtually unlimited structural variation. As a consequence, there are many hundreds of such entities that have been identified to date. Generally, forensic toxicology labs utilize a screening method, such as immunoassay, for the presumptive identification of drugs of abuse. When a positive result occurs, confirmatory methods, such as gas chromatography (GC) or liquid chromatography (LC) coupled with mass spectrometry (MS), are required for more sensitive and specific qualitative and quantitative analyses. In recent years, the need to study the activities of these compounds in screening assays as well as to develop confirmatory techniques to detect them in biological specimens has been recognized. Designer drugs have been a major topic of concern in Europe for some time and this issue has also become increasingly important in the United States. (…) . The present project included two primary tasks. Task 1 consisted of determination of the cross-reactivity of designer drugs in common commercially available immunoassays. Task 2 consisted of similar screening evaluation using a series of blind spiked serum samples, with comparison to screening results obtained using a validated LC-QQQ-MS method and highresolution LC-QTOF-MS analysis.»