Centro de Documentação da PJ
Monografia
 CD215 |
Review of the scientific approaches used during the FBI's investigation of the 2001 anthrax letters [Documento electrónico] / Committee on Review of the Scientific Approaches Used During the FBI's Investigation of the 2001 Bacillus anthracis Mailings.- Washington, DC : National Academies Press, 2011.- 1 CD-ROM ; 12 cm
Ficheiro de 2,59 MB em formato PDF (250 p.).
ISBN 978-0-309-18719-0
ARMA QUÍMICA, SERVIÇO POSTAL, ANÁLISE DE VESTÍGIOS, ANÁLISE LABORATORIAL, TERRORISMO, FBI, ESTADOS UNIDOS
Summary. 1 Introduction. 1.1 Background. 1.2 Chronology of events of Fall 2001. 1.3 Brief summary of the FBI’s scientific investigation. 1.4 Summary of FBI and DOJ scientific conclusions. 1.5 Committee process. 1.6 Issues for consideration in reading this report. 1.7 Organization of the report. 2 biology and history of “bacillus anthracis”. 2.1 Introduction. 2.2 The biology of “B. anthracis”. 2.3 Clinical aspects of anthrax. 2.4 “B. anthracis” as a biological weapon. 2.5 Phylogeny of “B. anthracis”. 2.6 The Early history of the ames strain of B.anthracis. 2.7 Summary. 3 Scientific investigation in a law enforcement case and description and timeline of the FBI scientific investigation. 3.1 Introduction. 3.2 Science and scientific investigation as part of a law enforcement investigation. 3.3 The federal coordinated response and assignment of laboratory work. 3.4 Collection and analysis of clinical and environmental samples and cross contamination. 3.4.1 Clinical and epidemiological samples. 3.4.2 Crime scene environmental samples. 3.4.3 Samples from an overseas site identified by intelligence. 3.4.4 Letter material and cross contamination. 3.5 Committee findings and recommendations. 4 Physical and chemical analyses. 4.1 Introduction. 4.2 Spore preparation and purification. 4.3 Surrogate preparation and purification. 4.4 Size and granularity of the material in the letters. 4.5 Presence of silicon and other elements in the letter material. 4.5.1 Elemental analysis. 4.5.2 Spatially resolved elemental analysis. 4.5.3 Silicon in the spore coat. 4.5.4 Summary of the silicon analysis. 4.6 Features of bacterial growth conditions and processing methods: detection of meglumine and diatrizoate. 4.7 Media component analysis. 4.8 Volatile organic compounds. 4.9 Determining When the material was produced: radiocarbon dating of “B. anthracis” samples. 4.10 Stable isotope analysis. 4.10.1 “B. anthracis”. 4.10.2 Water samples. 4.10.3 The envelope measurements. 4.11 Committee findings. 5 Microbiological and genetic analyses of material in the letters. 5.1 Introduction. 5.2 Identification of the “B. anthracis” strain. 5.3 Was the “B. anthracis” in the letters genetically engineered? 5.4 “B. subtilis” contamination of the New York samples. 5.5 Identification and characterization of colony morphological variants in the evidentiary material. 5.5.1 Why was the FBI interested in colony morphotypes? 5.5.2 Background information on morphotypes. 5.5.3 Detection and characterization of morphotypes in the anthrax letters samples. 5.5.4 Selection criteria for genetic variations used in screening. 5.5.5 Whole genome sequencing of morphotype isolates. 5.5.6 Development and application of assays for the genotypes. Genotypes A1 and A3. Genotypes B and D. Genotype E. 5.6 Committee findings. 6 Comparison of the material in the letters with samples in the FBI repository. 6.1 Introduction. 6.2 Creation of the FBI Repository (FBIR). 6.3 Use of the genetic assays to test for the four genotypes. 6.4 Derivation of RMR-1029 spores. 6.5 Analyses of the repository samples and statistical interpretation of the evidence. 6.5.1 The FBI’s “Statistical Analysis Report”. 6.5.2 Committee assessment of the “Statistical Analysis Report”. 6.6 Analyses based on resampling RMR-1029 and interpretation of the results. 6.7 Committee findings. Bibliography. Index of documents provided by the Federal Bureau of Investigation. Appendixes. A Radiocarbon dating. B The forensics potential of stable isotope analysis. C Committee evaluation of “Statistical Analysis Report”. D Biographical information of committee and staff.